diff --git a/homeassistant/components/synology_dsm/config_flow.py b/homeassistant/components/synology_dsm/config_flow.py
index a38b2ccc09cf..07ed847bdc1c 100644
--- a/homeassistant/components/synology_dsm/config_flow.py
+++ b/homeassistant/components/synology_dsm/config_flow.py
@@ -20,6 +20,7 @@ import voluptuous as vol
 
 from homeassistant.config_entries import (
     ConfigEntry,
+    ConfigEntryState,
     ConfigFlow,
     ConfigFlowResult,
     OptionsFlowWithReload,
@@ -463,6 +464,10 @@ class SynologyDSMOptionsFlowHandler(OptionsFlowWithReload):
         self, user_input: dict[str, Any] | None = None
     ) -> ConfigFlowResult:
         """Handle options flow."""
+        # The shares to pick from come from the running connection
+        if self.config_entry.state is not ConfigEntryState.LOADED:
+            return self.async_abort(reason="entry_not_loaded")
+
         if user_input is not None:
             return self.async_create_entry(title="", data=user_input)
 
diff --git a/homeassistant/components/synology_dsm/strings.json b/homeassistant/components/synology_dsm/strings.json
index 671a76be1e57..c5b75c6f17ec 100644
--- a/homeassistant/components/synology_dsm/strings.json
+++ b/homeassistant/components/synology_dsm/strings.json
@@ -241,6 +241,9 @@
     }
   },
   "options": {
+    "abort": {
+      "entry_not_loaded": "The integration is not loaded, so the shares to back up to cannot be listed."
+    },
     "step": {
       "init": {
         "data": {
diff --git a/tests/components/synology_dsm/test_config_flow.py b/tests/components/synology_dsm/test_config_flow.py
index c29045c6cff5..7c17d8116af7 100644
--- a/tests/components/synology_dsm/test_config_flow.py
+++ b/tests/components/synology_dsm/test_config_flow.py
@@ -21,7 +21,12 @@ from homeassistant.components.synology_dsm.const import (
     CONF_SNAPSHOT_QUALITY,
     DOMAIN,
 )
-from homeassistant.config_entries import SOURCE_SSDP, SOURCE_USER, SOURCE_ZEROCONF
+from homeassistant.config_entries import (
+    SOURCE_SSDP,
+    SOURCE_USER,
+    SOURCE_ZEROCONF,
+    ConfigEntryState,
+)
 from homeassistant.const import (
     CONF_HOST,
     CONF_MAC,
@@ -707,6 +712,32 @@ async def test_options_flow(
     assert config_entry.options[CONF_BACKUP_SHARE] == "/ha_backup"
 
 
+async def test_options_flow_entry_not_loaded(
+    hass: HomeAssistant, service_with_filestation: MagicMock
+) -> None:
+    """Test the options flow aborts when the integration is not loaded."""
+    config_entry = MockConfigEntry(
+        domain=DOMAIN,
+        data={
+            CONF_HOST: HOST,
+            CONF_PORT: PORT,
+            CONF_SSL: USE_SSL,
+            CONF_USERNAME: USERNAME,
+            CONF_PASSWORD: PASSWORD,
+            CONF_MAC: MACS[0],
+        },
+        unique_id=SERIAL,
+    )
+    config_entry.add_to_hass(hass)
+
+    assert config_entry.state is ConfigEntryState.NOT_LOADED
+
+    result = await hass.config_entries.options.async_init(config_entry.entry_id)
+
+    assert result["type"] is FlowResultType.ABORT
+    assert result["reason"] == "entry_not_loaded"
+
+
 @pytest.mark.usefixtures("mock_setup_entry")
 async def test_discovered_via_zeroconf(
     hass: HomeAssistant, service: MagicMock, snapshot: SnapshotAssertion